{"id":99,"date":"2026-09-04T18:36:51","date_gmt":"2026-09-04T13:36:51","guid":{"rendered":"https:\/\/sciotrope.com\/?page_id=99"},"modified":"2026-09-08T02:16:41","modified_gmt":"2026-09-07T21:16:41","slug":"about","status":"publish","type":"page","link":"https:\/\/sciotrope.com\/?page_id=99","title":{"rendered":"About"},"content":{"rendered":"\n

Sciotope was founded by Dr. Matthew Clark and associates. He has worked with a consortium of pharma companies to study and publish works on how well animal studies predict human outcomes, as well as in predictive modeling.<\/p>\n\n\n\n

Contact information<\/h5>\n\n\n\n

info@sciotrope.com<\/em>
Sciotrope Institute
1627 Addison St.
Philadelphia PA 19146<\/p>\n\n\n\n

Publications<\/h5>\n\n\n
\n\n\t\t9148853<\/span>\n\t\t<\/span>\n\t\tKITEPCG8<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n <\/span>\n\t\t1<\/span>\n\t\tchicago-author-date<\/span>\n\t\t10<\/span>\n\t\tdate<\/span>\n\t\tdesc<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n\t\t<\/span>\n <\/span>\n 99<\/span>\n\t\thttps:\/\/sciotrope.com\/gardyloo\/wp-content\/plugins\/zotpress\/<\/span>\n\n\t\t
\n\t\t\t
\n\t\t\t\t60<\/span>%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22DLZ3PJ7I%22%2C%22library%22%3A%7B%22id%22%3A9148853%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kremer%20et%20al.%22%2C%22parsedDate%22%3A%222025%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKremer%2C%20John%20J.%2C%20Matt%20Bridgland-Taylor%2C%20Matt%20Clark%2C%20Mike%20G.%20Rolf%2C%20Martin%20Traebert%2C%20and%20Gregory%20S.%20Friedrichs.%202025.%20%26%23x201C%3BTaking%20a%20Deep%20Breath%3A%20Evidence-Based%20Approaches%20to%20Respiratory%20Safety%20Assessment.%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20Pharmacological%20and%20Toxicological%20Methods%26lt%3B%5C%2Fi%26gt%3B%20134%3A%20107744.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.vascn.2025.107744%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.vascn.2025.107744%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Taking%20a%20deep%20breath%3A%20Evidence-based%20approaches%20to%20respiratory%20safety%20assessment%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20J.%22%2C%22lastName%22%3A%22Kremer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matt%22%2C%22lastName%22%3A%22Bridgland-Taylor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matt%22%2C%22lastName%22%3A%22Clark%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mike%20G.%22%2C%22lastName%22%3A%22Rolf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%22%2C%22lastName%22%3A%22Traebert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gregory%20S.%22%2C%22lastName%22%3A%22Friedrichs%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2206%5C%2F2025%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.vascn.2025.107744%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS1056871925001649%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2210568719%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%229TFVWMR4%22%2C%22KITEPCG8%22%5D%2C%22dateModified%22%3A%222026-08-04T00%3A34%3A36Z%22%7D%7D%2C%7B%22key%22%3A%22YRWIUN69%22%2C%22library%22%3A%7B%22id%22%3A9148853%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Friedrichs%20et%20al.%22%2C%22parsedDate%22%3A%222024%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BFriedrichs%2C%20G.%20S.%2C%20M.%20M.%20Abernathy%2C%20D.%20Ackley%2C%20et%20al.%202024.%20%26%23x201C%3BReevaluating%20Safety%20Pharmacology%20Respiratory%20Studies%20within%20the%20ICH%20S7A%20Core%20Battery%3A%20A%20Multi-Company%20Evaluation%20of%20Preclinical%20Utility%20and%20Clinical%20Translation.%26%23x201D%3B%20%26lt%3Bi%26gt%3BRegulatory%20Toxicology%20and%20Pharmacology%26lt%3B%5C%2Fi%26gt%3B%20153%3A%20105706.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.yrtph.2024.105706%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.yrtph.2024.105706%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Reevaluating%20safety%20pharmacology%20respiratory%20studies%20within%20the%20ICH%20S7A%20core%20battery%3A%20A%20multi-company%20evaluation%20of%20preclinical%20utility%20and%20clinical%20translation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G.S.%22%2C%22lastName%22%3A%22Friedrichs%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.M.%22%2C%22lastName%22%3A%22Abernathy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22D.%22%2C%22lastName%22%3A%22Ackley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Clark%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.K.%22%2C%22lastName%22%3A%22DaSilva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.M.%22%2C%22lastName%22%3A%22Foley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Greiter-Wilke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22K.A%22%2C%22lastName%22%3A%22Henderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.J.%22%2C%22lastName%22%3A%22Kremer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22B.H.%22%2C%22lastName%22%3A%22Morimoto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%22%2C%22lastName%22%3A%22Paglialunga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.K.%22%2C%22lastName%22%3A%22Pugsley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.P.%22%2C%22lastName%22%3A%22Regan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22E.I.%22%2C%22lastName%22%3A%22Rossman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J.A.%22%2C%22lastName%22%3A%22Segretti%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22M.%22%2C%22lastName%22%3A%22Traebert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22H.M.%22%2C%22lastName%22%3A%22Vargas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22T.A.%22%2C%22lastName%22%3A%22Wisialowski%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2211%5C%2F2024%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.yrtph.2024.105706%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS0273230024001478%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2202732300%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22KITEPCG8%22%2C%22WLBBXY9W%22%5D%2C%22dateModified%22%3A%222025-01-07T15%3A50%3A26Z%22%7D%7D%2C%7B%22key%22%3A%22KJL3JBJ7%22%2C%22library%22%3A%7B%22id%22%3A9148853%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Steger-Hartmann%20and%20Clark%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BSteger-Hartmann%2C%20Thomas%2C%20and%20Matthew%20Clark.%202023.%20%26%23x201C%3BCan%20Historical%20Control%20Group%20Data%20Be%20Used%20to%20Replace%20Concurrent%20Controls%20in%20Animal%20Studies%3F%26%23x201D%3B%20%26lt%3Bi%26gt%3BToxicologic%20Pathology%26lt%3B%5C%2Fi%26gt%3B%2051%20%286%29%3A%20361%26%23x2013%3B62.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1177%5C%2F01926233231208987%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1177%5C%2F01926233231208987%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Can%20Historical%20Control%20Group%20Data%20Be%20Used%20to%20Replace%20Concurrent%20Controls%20in%20Animal%20Studies%3F%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Steger-Hartmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%22%2C%22lastName%22%3A%22Clark%22%7D%5D%2C%22abstractNote%22%3A%22The%20availability%20of%20large%20amounts%20of%20high-quality%20control%20data%20from%20tightly%20controlled%20regulated%20animal%20safety%20data%20has%20created%20the%20idea%20to%20re-use%20these%20data%20beyond%20its%20classical%20applications%20of%20quality%20control%2C%20identification%20of%20treatment-related%20effects%20and%20assessing%20effect-size%20relevance%20for%20building%20virtual%20control%20groups%20%28VCGs%29.%20While%20the%20ethical%20and%20cost-saving%20aspects%20of%20such%20a%20concept%20are%20immediately%20evident%2C%20the%20potential%20challenges%20need%20to%20be%20carefully%20considered%20to%20avoid%20any%20effect%20which%20could%20lower%20the%20sensitivity%20of%20an%20animal%20study%20to%20detect%20adverse%20events%2C%20safety%20thresholds%2C%20target%20organs%2C%20or%20biomarkers.%20In%20our%20brief%20communication%2C%20we%20summarize%20the%20current%20discussion%20regarding%20VCGs%20and%20propose%20a%20path%20forward%20how%20the%20replacement%20of%20concurrent%20control%20with%20VCGs%20resulting%20from%20historical%20data%20could%20be%20systematically%20assessed%20and%20to%20come%20to%20conclusions%20regarding%20the%20scientific%20value%20of%20the%20concept.%22%2C%22date%22%3A%2208%5C%2F2023%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1177%5C%2F01926233231208987%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.sagepub.com%5C%2Fdoi%5C%2F10.1177%5C%2F01926233231208987%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220192-6233%2C%201533-1601%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22KITEPCG8%22%2C%22WLBBXY9W%22%5D%2C%22dateModified%22%3A%222025-01-07T15%3A50%3A46Z%22%7D%7D%2C%7B%22key%22%3A%22JDZY49R9%22%2C%22library%22%3A%7B%22id%22%3A9148853%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Emily%20Golden%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BEmily%20Golden%2C%20David%20Allen%2C%20Alexander%20Amberg%2C%20et%20al.%202023.%20%26%23x201C%3BToward%20Implementing%20Virtual%20Control%20Groups%20in%20Nonclinical%20Safety%20Studies.%26%23x201D%3B%20%26lt%3Bi%26gt%3BALTEX%26lt%3B%5C%2Fi%26gt%3B%2C%20ahead%20of%20print.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14573%5C%2Faltex.2310041%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.14573%5C%2Faltex.2310041%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Toward%20implementing%20virtual%20control%20groups%20in%20nonclinical%20safety%20studies%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Emily%20Golden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22David%20Allen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Alexander%20Amberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Lennart%20T.%20Anger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Elizabeth%20Baker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Szczepan%20W.%20Baran%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Frank%20Bringezu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Matthew%20Clark%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Guillemette%20Duchateau-Nguyen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Sylvia%20E.%20Escher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Varun%20Giri%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Armelle%20Grevot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Thomas%20Hartung%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Dingzhou%20Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Laura%20Lotfi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Wolfgang%20Muster%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Kevin%20Snyder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Ronald%20Wange%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Thomas%20Steger-Hartmann%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222023%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.14573%5C%2Faltex.2310041%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.altex.org%5C%2Findex.php%5C%2Faltex%5C%2Farticle%5C%2Fview%5C%2F2713%5C%2Fversion%5C%2F2775%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221868596X%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22KITEPCG8%22%2C%22WLBBXY9W%22%5D%2C%22dateModified%22%3A%222025-01-07T17%3A15%3A32Z%22%7D%7D%2C%7B%22key%22%3A%22ND7EQSMS%22%2C%22library%22%3A%7B%22id%22%3A9148853%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Paglialunga%20et%20al.%22%2C%22parsedDate%22%3A%222019%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPaglialunga%2C%20Sabina%2C%20Bruce%20H.%20Morimoto%2C%20Matthew%20Clark%2C%20and%20Gregory%20S.%20Friedrichs.%202019.%20%26%23x201C%3BTranslatability%20of%20the%20S7A%20Core%20Battery%20Respiratory%20Safety%20Pharmacology%20Studies%3A%20Preclinical%20Respiratory%20and%20Related%20Clinical%20Adverse%20Events.%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20Pharmacological%20and%20Toxicological%20Methods%26lt%3B%5C%2Fi%26gt%3B%2099%3A%20106596.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.vascn.2019.106596%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.vascn.2019.106596%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Translatability%20of%20the%20S7A%20core%20battery%20respiratory%20safety%20pharmacology%20studies%3A%20Preclinical%20respiratory%20and%20related%20clinical%20adverse%20events%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabina%22%2C%22lastName%22%3A%22Paglialunga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruce%20H.%22%2C%22lastName%22%3A%22Morimoto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%22%2C%22lastName%22%3A%22Clark%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gregory%20S.%22%2C%22lastName%22%3A%22Friedrichs%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2209%5C%2F2019%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.vascn.2019.106596%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS105687191930098X%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2210568719%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22KITEPCG8%22%2C%22WLBBXY9W%22%5D%2C%22dateModified%22%3A%222025-01-07T15%3A53%3A13Z%22%7D%7D%2C%7B%22key%22%3A%22ERVRL7B8%22%2C%22library%22%3A%7B%22id%22%3A9148853%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Clark%20and%20Steger-Hartmann%22%2C%22parsedDate%22%3A%222018%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BClark%2C%20Matthew%2C%20and%20Thomas%20Steger-Hartmann.%202018.%20%26%23x201C%3BA%20Big%20Data%20Approach%20to%20the%20Concordance%20of%20the%20Toxicity%20of%20Pharmaceuticals%20in%20Animals%20and%20Humans.%26%23x201D%3B%20%26lt%3Bi%26gt%3BRegulatory%20Toxicology%20and%20Pharmacology%26lt%3B%5C%2Fi%26gt%3B%2096%3A%2094%26%23x2013%3B105.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.yrtph.2018.04.018%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.yrtph.2018.04.018%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20big%20data%20approach%20to%20the%20concordance%20of%20the%20toxicity%20of%20pharmaceuticals%20in%20animals%20and%20humans%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthew%22%2C%22lastName%22%3A%22Clark%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Steger-Hartmann%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2207%5C%2F2018%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.yrtph.2018.04.018%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS0273230018301272%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2202732300%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22KITEPCG8%22%2C%22WLBBXY9W%22%5D%2C%22dateModified%22%3A%222025-01-07T15%3A53%3A24Z%22%7D%7D%2C%7B%22key%22%3A%22IDL3NQUR%22%2C%22library%22%3A%7B%22id%22%3A9148853%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Matthew%20Clark%20and%20Jeffrey%20S.%20Wiseman%22%2C%22parsedDate%22%3A%222017-01-18%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMatthew%20Clark%2C%20and%20Jeffrey%20S.%20Wiseman.%202017.%20%26%23x201C%3BFree%20Energy%20Computation%20by%20Monte%20Carlo%20Integration.%26%23x201D%3B%20arXiv%3A1701.05073.%20Preprint%2C%20arXiv%2C%20January%2018.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.48550%5C%2FarXiv.1701.05073%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.48550%5C%2FarXiv.1701.05073%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22preprint%22%2C%22title%22%3A%22Free%20Energy%20Computation%20by%20Monte%20Carlo%20Integration%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Matthew%20Clark%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Jeffrey%20S.%20Wiseman%22%7D%5D%2C%22abstractNote%22%3A%22The%20principles%20behind%20the%20computation%20of%20protein-ligand%20binding%20free%20energies%20by%20Monte%20Carlo%20integration%20are%20described%20in%20detail.%20The%20simulation%20provides%20gas-phase%20binding%20free%20energies%20that%20can%20be%20converted%20to%20aqueous%20energies%20by%20solvation%20corrections.%20The%20direct%20integration%20simulation%20has%20several%20characteristics%20beneficial%20to%20free-energy%20calculations.%20One%20is%20that%20the%20number%20of%20parameters%20that%20must%20be%20set%20for%20the%20simulation%20is%20small%20and%20can%20be%20determined%20objectively%2C%20making%20the%20outcome%20more%20deterministic%2C%20with%20respect%20to%20choice%20of%20input%20conditions%2C%20as%20compared%20to%20perturbation%20methods.%20Second%2C%20the%20simulation%20is%20free%20from%20assumptions%20about%20the%20starting%20pose%20or%20nature%20of%20the%20binding%20site.%20A%20final%20benefit%20is%20that%20binding%20free%20energies%20are%20a%20direct%20outcome%20of%20the%20simulation%2C%20and%20little%20processing%20is%20required%20to%20determine%20them.%20The%20well-studied%20T4%20lysozyme%20experimental%20free%20energy%20data%20and%20crystal%20structures%20were%20used%20to%20evaluate%20the%20method.%22%2C%22genre%22%3A%22%22%2C%22repository%22%3A%22arXiv%22%2C%22archiveID%22%3A%22arXiv%3A1701.05073%22%2C%22date%22%3A%222017-01-18%22%2C%22DOI%22%3A%2210.48550%5C%2FarXiv.1701.05073%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Farxiv.org%5C%2Fabs%5C%2F1701.05073%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22KITEPCG8%22%2C%22WLBBXY9W%22%5D%2C%22dateModified%22%3A%222025-01-07T17%3A37%3A12Z%22%7D%7D%2C%7B%22key%22%3A%22XPLUXW2G%22%2C%22library%22%3A%7B%22id%22%3A9148853%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Matthew%20Clark%22%2C%22parsedDate%22%3A%222015%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMatthew%20Clark.%202015.%20%26%23x201C%3BPrediction%20of%20Clinical%20Risks%20by%20Analysis%20of%20Preclinical%20and%20Clinical%20Adverse%20Events.%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20Biomedical%20Informatics%26lt%3B%5C%2Fi%26gt%3B%2054%3A%20167%26%23x2013%3B73.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jbi.2015.02.008%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jbi.2015.02.008%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Prediction%20of%20clinical%20risks%20by%20analysis%20of%20preclinical%20and%20clinical%20adverse%20events%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Matthew%20Clark%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2204%5C%2F2015%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jbi.2015.02.008%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS1532046415000404%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2215320464%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22KITEPCG8%22%2C%22WLBBXY9W%22%5D%2C%22dateModified%22%3A%222025-01-07T17%3A34%3A53Z%22%7D%7D%2C%7B%22key%22%3A%22M3Y8DCV2%22%2C%22library%22%3A%7B%22id%22%3A9148853%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Natalia%20Mast%20et%20al.%22%2C%22parsedDate%22%3A%222014%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BNatalia%20Mast%2C%20Yong%20Li%2C%20Marlin%20Linger%2C%20Matthew%20Clark%2C%20Jeffrey%20Wiseman%2C%20and%20Irina%20A.%20Pikuleva.%202014.%20%26%23x201C%3BPharmacologic%20Stimulation%20of%20Cytochrome%20P450%2046A1%20and%20Cerebral%20Cholesterol%20Turnover%20in%20Mice.%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20Biological%20Chemistry%26lt%3B%5C%2Fi%26gt%3B%20289%20%286%29%3A%203529%26%23x2013%3B38.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1074%5C%2Fjbc.M113.532846%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1074%5C%2Fjbc.M113.532846%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Pharmacologic%20Stimulation%20of%20Cytochrome%20P450%2046A1%20and%20Cerebral%20Cholesterol%20Turnover%20in%20Mice%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Natalia%20Mast%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Yong%20Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Marlin%20Linger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Matthew%20Clark%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Jeffrey%20Wiseman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Irina%20A.%20Pikuleva%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2202%5C%2F2014%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1074%5C%2Fjbc.M113.532846%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flinkinghub.elsevier.com%5C%2Fretrieve%5C%2Fpii%5C%2FS0021925819747437%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%2200219258%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22KITEPCG8%22%2C%22WLBBXY9W%22%5D%2C%22dateModified%22%3A%222025-01-07T17%3A37%3A21Z%22%7D%7D%2C%7B%22key%22%3A%22GCYH9SQB%22%2C%22library%22%3A%7B%22id%22%3A9148853%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Natalia%20Mast%20et%20al.%22%2C%22parsedDate%22%3A%222012%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BNatalia%20Mast%2C%20Marlin%20Linger%2C%20Matthew%20Clark%2C%20Jeffrey%20Wiseman%2C%20C.%20David%20Stout%2C%20and%20Irina%20A.%20Pikuleva.%202012.%20%26%23x201C%3BIn%20Silico%20and%20Intuitive%20Predictions%20of%20CYP46A1%20Inhibition%20by%20Marketed%20Drugs%20with%20Subsequent%20Enzyme%20Crystallization%20in%20Complex%20with%20Fluvoxamine.%26%23x201D%3B%20%26lt%3Bi%26gt%3BMolecular%20Pharmacology%26lt%3B%5C%2Fi%26gt%3B%2082%20%285%29%3A%20824%26%23x2013%3B34.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1124%5C%2Fmol.112.080424%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1124%5C%2Fmol.112.080424%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22In%20Silico%20and%20Intuitive%20Predictions%20of%20CYP46A1%20Inhibition%20by%20Marketed%20Drugs%20with%20Subsequent%20Enzyme%20Crystallization%20in%20Complex%20with%20Fluvoxamine%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Natalia%20Mast%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Marlin%20Linger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Matthew%20Clark%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Jeffrey%20Wiseman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22C.%20David%20Stout%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22name%22%3A%22Irina%20A.%20Pikuleva%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%2211%5C%2F2012%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1124%5C%2Fmol.112.080424%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fmolpharm.aspetjournals.org%5C%2Flookup%5C%2Fdoi%5C%2F10.1124%5C%2Fmol.112.080424%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220026-895X%2C%201521-0111%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22KITEPCG8%22%2C%22WLBBXY9W%22%5D%2C%22dateModified%22%3A%222025-01-07T17%3A37%3A26Z%22%7D%7D%5D%7D<\/span>\n\n\t\t\t\t
\n
\n
Kremer, John J., Matt Bridgland-Taylor, Matt Clark, Mike G. Rolf, Martin Traebert, and Gregory S. Friedrichs. 2025. \u201cTaking a Deep Breath: Evidence-Based Approaches to Respiratory Safety Assessment.\u201d Journal of Pharmacological and Toxicological Methods<\/i> 134: 107744. https:\/\/doi.org\/10.1016\/j.vascn.2025.107744<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
\n
\n
Friedrichs, G. S., M. M. Abernathy, D. Ackley, et al. 2024. \u201cReevaluating Safety Pharmacology Respiratory Studies within the ICH S7A Core Battery: A Multi-Company Evaluation of Preclinical Utility and Clinical Translation.\u201d Regulatory Toxicology and Pharmacology<\/i> 153: 105706. https:\/\/doi.org\/10.1016\/j.yrtph.2024.105706<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
\n
\n
Steger-Hartmann, Thomas, and Matthew Clark. 2023. \u201cCan Historical Control Group Data Be Used to Replace Concurrent Controls in Animal Studies?\u201d Toxicologic Pathology<\/i> 51 (6): 361\u201362. https:\/\/doi.org\/10.1177\/01926233231208987<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
\n
\n
Emily Golden, David Allen, Alexander Amberg, et al. 2023. \u201cToward Implementing Virtual Control Groups in Nonclinical Safety Studies.\u201d ALTEX<\/i>, ahead of print. https:\/\/doi.org\/10.14573\/altex.2310041<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
\n
\n
Paglialunga, Sabina, Bruce H. Morimoto, Matthew Clark, and Gregory S. Friedrichs. 2019. \u201cTranslatability of the S7A Core Battery Respiratory Safety Pharmacology Studies: Preclinical Respiratory and Related Clinical Adverse Events.\u201d Journal of Pharmacological and Toxicological Methods<\/i> 99: 106596. https:\/\/doi.org\/10.1016\/j.vascn.2019.106596<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
\n
\n
Clark, Matthew, and Thomas Steger-Hartmann. 2018. \u201cA Big Data Approach to the Concordance of the Toxicity of Pharmaceuticals in Animals and Humans.\u201d Regulatory Toxicology and Pharmacology<\/i> 96: 94\u2013105. https:\/\/doi.org\/10.1016\/j.yrtph.2018.04.018<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
\n
\n
Matthew Clark, and Jeffrey S. Wiseman. 2017. \u201cFree Energy Computation by Monte Carlo Integration.\u201d arXiv:1701.05073. Preprint, arXiv, January 18. https:\/\/doi.org\/10.48550\/arXiv.1701.05073<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
\n
\n
Matthew Clark. 2015. \u201cPrediction of Clinical Risks by Analysis of Preclinical and Clinical Adverse Events.\u201d Journal of Biomedical Informatics<\/i> 54: 167\u201373. https:\/\/doi.org\/10.1016\/j.jbi.2015.02.008<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
\n
\n
Natalia Mast, Yong Li, Marlin Linger, Matthew Clark, Jeffrey Wiseman, and Irina A. Pikuleva. 2014. \u201cPharmacologic Stimulation of Cytochrome P450 46A1 and Cerebral Cholesterol Turnover in Mice.\u201d Journal of Biological Chemistry<\/i> 289 (6): 3529\u201338. https:\/\/doi.org\/10.1074\/jbc.M113.532846<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
\n
\n
Natalia Mast, Marlin Linger, Matthew Clark, Jeffrey Wiseman, C. David Stout, and Irina A. Pikuleva. 2012. \u201cIn Silico and Intuitive Predictions of CYP46A1 Inhibition by Marketed Drugs with Subsequent Enzyme Crystallization in Complex with Fluvoxamine.\u201d Molecular Pharmacology<\/i> 82 (5): 824\u201334. https:\/\/doi.org\/10.1124\/mol.112.080424<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Sciotope was founded by Dr. Matthew Clark and associates. He has worked with a consortium of pharma companies to study […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-99","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sciotrope.com\/index.php?rest_route=\/wp\/v2\/pages\/99","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sciotrope.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sciotrope.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sciotrope.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sciotrope.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=99"}],"version-history":[{"count":6,"href":"https:\/\/sciotrope.com\/index.php?rest_route=\/wp\/v2\/pages\/99\/revisions"}],"predecessor-version":[{"id":137,"href":"https:\/\/sciotrope.com\/index.php?rest_route=\/wp\/v2\/pages\/99\/revisions\/137"}],"wp:attachment":[{"href":"https:\/\/sciotrope.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=99"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}